Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

  title={Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA},
  author={A. E. Pasquinelli and B. J. Reinhart and F. Slack and M. Martindale and M. Kuroda and Betsy Maller and D. Hayward and E. Ball and B. Degnan and P. M{\"u}ller and J. Spring and Ashok Srinivasan and M. Fishman and J. Finnerty and J. Corbo and M. Levine and P. Leahy and E. Davidson and G. Ruvkun},
  • A. E. Pasquinelli, B. J. Reinhart, +16 authors G. Ruvkun
  • Published 2000
  • Biology, Medicine
  • Nature
  • Two small RNAs regulate the timing of Caenorhabditis elegans development. Transition from the first to the second larval stage fates requires the 22-nucleotide lin-4 RNA, and transition from late larval to adult cell fates requires the 21-nucleotide let-7 RNA. The lin-4 and let-7 RNA genes are not homologous to each other, but are each complementary to sequences in the 3′ untranslated regions of a set of protein-coding target genes that are normally negatively regulated by the RNAs. Here we… CONTINUE READING

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