• DOI:10.1038/35040556
Corpus ID: 4401732

Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

@article{Pasquinelli2000ConservationOT,
  title={Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA},
  author={A. E. Pasquinelli and B. J. Reinhart and F. Slack and M. Martindale and M. Kuroda and Betsy Maller and D. Hayward and E. Ball and B. Degnan and P. M{\"u}ller and J. Spring and Ashok Srinivasan and M. Fishman and J. Finnerty and J. Corbo and M. Levine and P. Leahy and E. Davidson and G. Ruvkun},
  journal={Nature},
  year={2000},
  volume={408},
  pages={86-89}
}

A. E. Pasquinelli, B. J. Reinhart, +16 authors G. Ruvkun

Published 2000

Biology, Medicine

Nature

Two small RNAs regulate the timing of Caenorhabditis elegans development. Transition from the first to the second larval stage fates requires the 22-nucleotide lin-4 RNA, and transition from late larval to adult cell fates requires the 21-nucleotide let-7 RNA. The lin-4 and let-7 RNA genes are not homologous to each other, but are each complementary to sequences in the 3′ untranslated regions of a set of protein-coding target genes that are normally negatively regulated by the RNAs. Here we… CONTINUE READING

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