Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
@article{Pasquinelli2000ConservationOT, title={Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA}, author={Amy E Pasquinelli and Brenda J. Reinhart and Frank J. Slack and Mark Q. Martindale and Mitzi I. Kuroda and Betsy Maller and David C. Hayward and Eldon E. Ball and Bernard M. Degnan and Peter M{\"u}ller and J{\"u}rg Spring and Ashok Srinivasan and Mark C. Fishman and John R. Finnerty and Joseph C. Corbo and Michael S. Levine and Patrick S. Leahy and Eric H. Davidson and Gary Ruvkun}, journal={Nature}, year={2000}, volume={408}, pages={86-89} }
Two small RNAs regulate the timing of Caenorhabditis elegans development. Transition from the first to the second larval stage fates requires the 22-nucleotide lin-4 RNA, and transition from late larval to adult cell fates requires the 21-nucleotide let-7 RNA. The lin-4 and let-7 RNA genes are not homologous to each other, but are each complementary to sequences in the 3′ untranslated regions of a set of protein-coding target genes that are normally negatively regulated by the RNAs. Here we…
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