Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution.

@article{Parmentier2000ConservationOT,
  title={Conservation of the ligand recognition site of metabotropic glutamate receptors during evolution.},
  author={M L Parmentier and Thierry Galvez and Francine C Acher and B Peyre and Roberto Pellicciari and Yves Grau and J{\"o}el Bockaert and Jean-Philippe Pin},
  journal={Neuropharmacology},
  year={2000},
  volume={39 7},
  pages={1119-31}
}
Mammalian metabotropic glutamate receptors (mGluRs) are classified into 3 groups based on their sequence similarity and ligand recognition selectivity. Recently, we identified a Drosophila mGluR (DmGlu(A)R) which is about equidistant, phylogenetically, from the 3 mGluR groups. However, both the G-protein coupling selectivity and the pharmacological profile of DmGlu(A)R, as analysed with mutated G-proteins and a few compounds, look similar to those of mammalian group-II mGluRs. In the present… CONTINUE READING

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