Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro.

@article{Molenaar2002ConservationOT,
  title={Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro.},
  author={Peter Molenaar and Glenn Rabnott and Ian Anthony Yang and Kwun Meng Fong and Santiyagu M. Savarimuthu and Li Li and Malcolm J. West and Fraser David Russell},
  journal={Journal of the American College of Cardiology},
  year={2002},
  volume={40 7},
  pages={1275-82}
}
OBJECTIVE The goal of this study was to determine whether the cardiostimulant effects of the endogenous beta(1)-adrenergic receptor (AR) agonist, (-)-norepinephrine are modified by polymorphic (Serine49Glycine [Ser49Gly], Glycine389Arginine [Gly389Arg]) variants of beta(1)-ARs in the nonfailing adult human heart. BACKGROUND Human heart beta(1)-ARs perform a crucial role in mediating the cardiostimulant effects of (-)-norepinephrine. An understanding of the significance of Ser49Gly and… CONTINUE READING