Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.

@article{Chen1997ConservationOT,
  title={Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression.},
  author={Hunter H. Chen and Arunthathi Thiagalingam and Hemi Chopra and Michael W Borges and John N. Feder and Barry D. Nelkin and Stephen B. Baylin and Douglas W. Ball},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1997},
  volume={94 10},
  pages={
          5355-60
        }
}
The achaete-scute genes encode essential transcription factors in normal Drosophila and vertebrate nervous system development. Human achaete-scute homolog-1 (hASH1) is constitutively expressed in a human lung cancer with neuroendocrine (NE) features, small cell lung cancer (SCLC), and is essential for development of the normal pulmonary NE cells that most resemble this neoplasm. Mechanisms regulating achaete-scute homolog expression outside of Drosophila are presently unclear, either in the… CONTINUE READING
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