Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes.

Abstract

The envelope (E) protein is composed of three domains (ED1, ED2 and ED3) with ED3 targeted by the most potent neutralizing antibodies. DENV-2 strains can be divided into six genotypes. Comparison of ED3 of representative strains of the six genotypes revealed that there are nine variable residues that are specific to a given genotype. Recombinant ED3s (rED3s… (More)
DOI: 10.1016/j.virol.2011.10.020

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@article{Pitcher2012ConservationOT, title={Conservation of the DENV-2 type-specific and DEN complex-reactive antigenic sites among DENV-2 genotypes.}, author={Trevor J Pitcher and Gregory D. Gromowski and David W. C. Beasley and Alan D. T. Barrett}, journal={Virology}, year={2012}, volume={422 2}, pages={386-92} }