Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts.

@article{Vly1997ConservationOS,
  title={Conservation of structural features reveals the existence of a large family of inhibitory cell surface receptors and noninhibitory/activatory counterparts.},
  author={Fr{\'e}d{\'e}ric V{\'e}ly and Eric Vivier},
  journal={Journal of immunology},
  year={1997},
  volume={159 5},
  pages={
          2075-7
        }
}

• Frédéric Vély, Eric Vivier
• Published in Journal of immunology 1997

Immunoreceptor tyrosine-based inhibition motifs (ITIMs) consist of a 6-amino acid stretch (ILV)xYxx(LV). ITIMs are expressed in the intracytoplasmic domain of transmembrane receptors, which extinguish cell activation induced by receptors bearing immunoreceptor tyrosine-based activation motifs. The recent identification of new members of the ITIM-bearing receptor family (such as the signal-regulatory proteins) extends the ITIM concept to the negative regulation of growth factor- and oncogene… CONTINUE READING

Save to Library

Create Alert

Cite

View on PubMed