Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.

@article{Handschin2001ConservationOS,
  title={Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans.},
  author={Christoph Handschin and Michael Podvinec and Jacqueline St{\"o}ckli and Karin Hoffmann and Urs A. Meyer},
  journal={Molecular endocrinology},
  year={2001},
  volume={15 9},
  pages={1571-85}
}
Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP). This induction is part of an adaptive response involving numerous genes to exposure to drugs and chemicals and has major clinical and toxicological implications. Here we report experiments in the chicken hepatoma cell line LMH that suggest evolutionary… CONTINUE READING
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