Conservation of functional domains involved in RNA binding and protein-protein interactions in human and Saccharomyces cerevisiae pre-mRNA splicing factor SF1.

@article{Rain1998ConservationOF,
  title={Conservation of functional domains involved in RNA binding and protein-protein interactions in human and Saccharomyces cerevisiae pre-mRNA splicing factor SF1.},
  author={J C Rain and Ziauddin Ahamed Rafi and Zakaria Rhani and Pierre Legrain and Angela Kr{\"a}mer},
  journal={RNA},
  year={1998},
  volume={4 5},
  pages={551-65}
}
The modular structure of splicing factor SF1 is conserved from yeast to man and SF1 acts at early stages of spliceosome assembly in both organisms. The hnRNP K homology (KH) domain of human (h) SF1 is the major determinant for RNA binding and is essential for the activity of hSF1 in spliceosome assembly, supporting the view that binding of SF1 to RNA is essential for its function. Sequences N-terminal to the KH domain mediate the interaction between hSF1 and U2AF65, which binds to the… CONTINUE READING

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