Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited.

@article{Orrell2007ConservationOF,
  title={Conservation of first-line antiretroviral treatment regimen where therapeutic options are limited.},
  author={Catherine Orrell and Guy Harling and Stephen D. Lawn and Richard Kaplan and Matthew J McNally and Linda-Gail Bekker and Robin Wood},
  journal={Antiviral therapy},
  year={2007},
  volume={12 1},
  pages={83-8}
}
OBJECTIVES To determine rates and causes of switching from first- to second-line antiretroviral treatment (ART) regimens in a large treatment-naive cohort (a South African community-based ART service) where a targeted adherence intervention was used to manage initial virological breakthrough. METHODS ART-naive adults (n=929) commencing first-line non-nucleoside-based ART [according to WHO (2002) guidelines] between September 2002 and August 2005 were studied prospectively. Viral load (VL) and… CONTINUE READING

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