Conservation of digestive enzymes.

@article{Rothman2002ConservationOD,
  title={Conservation of digestive enzymes.},
  author={Stephen S. Rothman and Charles Liebow and Lois Isenman},
  journal={Physiological reviews},
  year={2002},
  volume={82 1},
  pages={
          1-18
        }
}
The traditional understanding is that an entirely new complement of digestive enzymes is secreted by the pancreas into the small intestines with each meal. This is thought to be necessary because, like food itself, these enzymes are degraded during digestion. In this review we discuss experiments that bring this point of view into question. They suggest that digestive enzymes can be absorbed into blood, reaccumulated by the pancreas, and reutilized, instead of being reduced to their constituent… 
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References

SHOWING 1-10 OF 175 REFERENCES

Enteropancreatic circulation of digestive enzyme as a conservation mechanism

The experiments reported here are consistent with this latter view and suggest the circulation of approximately 60% of a mixture of digestive enzymes instilled into the duodenum (82–92% at steady state).

Distribution and fate of pancreatic enzymes in small intestine of the rat.

Diversion of pancreatic juice to the exterior of the body resulted in rapid disappearance of enzymes from the small intestine with virtually complete absence after 16 hr.

Enteropancreatic circulation of digestive enzymes does not exist in the rat

The hypothesis of an enteropancreatic circulation1–3, that digestive enzymes are absorbed intact across the intestinal epithelium, are circulated through the bloodstream and rese-creted by the…

The endocrine secretion of mammalian digestive enzymes by exocrine glands.

A variety of evidence suggests that the endocrine secretion of digestive enzymes is a normal occurrence that can be of substantial magnitude in healthy individuals, is responsive to various physiological stimuli, and is distinct from exocrine secretion.

Absorption of exogenous and endogenousproteolytic enzymes

The method described does not seem to be useful as a pancreatic function test because it indicates absorption of the enzymes administered rather than release of secondary enzymes from the intestinal tract.

Permeability of adolescent rat intestine to pancreatic ribonuclease.

The experimental data favor simple diffusion of RNase across rat small bowel, but the amounts of pancreatic RNase absorbed were small, and while the data do not negate the concept of an enteropancreatic recirculation in the rat, only a minor quantity of luminal, pancreaticRNase could recirculate.

The physiology of secretin.

Effect of feeding on the protein synthesis in mammalian pancreas.

Comparison of stored and secreted rat pancreatic digestive enzymes by mass spectrometry: alpha-amylase.

Exocrine Secretion from the isolated Rabbit Pancreas

In the work recorded here it was possible to maintain pancreatic secretion in an in vitro preparation of rabbit pancreas for 5–6 h and to demonstrate ion concentration-flow relationships similar to those found in vivo.
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