Conservation of context-dependent splicing activity in distant Muscleblind homologs

@inproceedings{Oddo2016ConservationOC,
  title={Conservation of context-dependent splicing activity in distant Muscleblind homologs},
  author={Julia C. Oddo and Tanvi Saxena and Ona L. McConnell and J Andrew Berglund and Eric T. Wang},
  booktitle={Nucleic acids research},
  year={2016}
}
The Muscleblind (MBL) protein family is a deeply conserved family of RNA binding proteins that regulate alternative splicing, alternative polyadenylation, RNA stability and RNA localization. Their inactivation due to sequestration by expanded CUG repeats causes symptoms in the neuromuscular disease myotonic dystrophy. MBL zinc fingers are the most highly conserved portion of these proteins, and directly interact with RNA. We identified putative MBL homologs in Ciona intestinalis and Trichoplax… CONTINUE READING
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