Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.

@article{Wiltzer2012ConservationOA,
  title={Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.},
  author={Linda Wiltzer and Florence Larrous and S Oksayan and Naoto Ito and Glenn A Marsh and Lin-fa Wang and Danielle Blondel and Herv{\'e} Bourhy and David Andrew Jans and Gregory William Moseley},
  journal={Journal of virology},
  year={2012},
  volume={86 18},
  pages={10194-9}
}
The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis… CONTINUE READING