Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor.

@article{Kaneko2006ConservationOA,
  title={Conservation of a platelet activating domain of Aggrus/podoplanin as a platelet aggregation-inducing factor.},
  author={Mika Kato Kaneko and Yukinari Kato and Takashi Kitano and Motoki Osawa},
  journal={Gene},
  year={2006},
  volume={378},
  pages={52-7}
}
Human Aggrus/podoplanin is an identified platelet aggregation-inducing factor of cancer cells, which is also known as a specific marker of lymphatic endothelium. Human Aggrus was known to be expressed in seminoma, squamous cell carcinoma, malignant mesothelioma, sarcomas and several brain tumors. In our previous studies, the sialylated O-glycan of human and mouse Aggrus were shown to be critical for its platelet aggregation-inducing activity in the experiments using the glycosylation-deficient… CONTINUE READING