Conservation of a maternal-specific methylation signal at the human IGF2R locus.

  title={Conservation of a maternal-specific methylation signal at the human IGF2R locus.},
  author={Oskar W. Smrzka and Ingrid Fa{\'e} and Reinhard J. St{\"o}ger and Robert Kurzbauer and G F Fischer and T. Henn and Andreas Weith and Denise P. Barlow},
  journal={Human molecular genetics},
  volume={4 10},
The human IGF2R gene has been reported to be either biallelically or very rarely monoallelically expressed, in contrast to the maternally expressed mouse counterpart. We describe here an analysis of the 5' portion of the human IGF2R gene and show that it contains a maternally methylated CpG island in the second intron. A similar maternally methylated intronic element has been proposed to be the imprinting box for the mouse gene and although the relevance of this element has yet to be directly… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 32 extracted citations

Imprinting evolution and human health

Mammalian Genome • 2009
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…