Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila

@article{Bopp1986ConservationOA,
  title={Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila},
  author={Daniel Bopp and Maya Burri and Stefan Baumgartner and Gabriella Frigerio and Markus Noll},
  journal={Cell},
  year={1986},
  volume={47},
  pages={1033-1040}
}
Extending our search for homologous domains of the Drosophila paired gene, two closely linked genes at the gooseberry locus have been isolated. Both genes are expressed with a single segment periodicity but with different spatial and temporal expression patterns. While the transcripts of one gene appear earlier and are equally distributed between ectoderm and mesoderm, those of the second gene accumulate preferentially in neuroblasts. The similarity of these expression patterns to the 14-band… 
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Multiple regulatory elements direct the complex expression pattern of the Drosophila segmentation gene paired
TLDR
It is proposed that regulation of prd by pair-rule and gap gene products is mediated by upstream and downstream cis-regulatory elements.
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TLDR
The functional diversification of paired, gooseberry and Pax3, primarily determined by variations in their enhancers, is modified by adaptations of their coding regions as a necessary consequence of their newly acquired spatiotemporal expression.
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TLDR
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Murine genes with homology to Drosophila segmentation genes.
As a potential method to define genes that control vertebrate segmentation processes during embryogenesis, murine genes containing a protein domain homologous to the Drosophila paired box sequence
Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system.
TLDR
The transient nature of Pax2 expression during kidney organogenesis correlates with polarization and induction of epithelial structures and may indicate an important morphogenetic role for this gene.
In vivo requirement for the paired domain and homeodomain of the paired segmentation gene product.
TLDR
While Prd can use itsDNA-binding domains combinatorially in order to achieve different DNA-binding specificities, its principal binding mode requires a cooperative interaction between the PAI domain and the homeodomain.
Both the paired domain and homeodomain are required for in vivo function of Drosophila Paired.
Drosophila paired, a homolog of mammalian Pax-3, is key to the coordinated regulation of segment-polarity genes during embryogenesis. The paired gene and its homologs are unusual in encoding proteins
Evolution of distinct developmental functions of three Drosophila genes by acquisition of different cis-regulatory regions
TLDR
It is shown that, despite the functional difference and the considerably diverged coding sequence of these genes, their proteins have conserved the same function and exemplifies an important evolutionary mechanism of how function diversifies after gene duplication.
Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila embryogenesis.
TLDR
The gooseberry (gsb) locus contains two closely linked genes, BSH9 and BSH4, which are structurally related to each other and to the paired (prd) gene, which can encode proteins of 427 and 452 amino acids, respectively.
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References

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The observed linking of gene sets through combinations of homologies coding for protein domains is consistent with a general network concept of gene action.
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It is shown that this DNA homology (the homeo box) is due to a conserved protein-coding sequence present in these three pattern-formation genes and is reflected in a structural homology in their gene products.
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TLDR
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TLDR
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TLDR
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  • M. Scott, A. Weiner
  • Biology, Medicine
    Proceedings of the National Academy of Sciences of the United States of America
  • 1984
TLDR
Sequence analysis of the cross-hybridizing DNA from the three loci revealed the conservation of predicted amino acid sequences derived from coding parts of the genes, suggesting that two homoeotic loci and a "segment-deficient" locus encode protein products with partially shared structures and that theThree loci may be evolutionarily and functionally related.
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TLDR
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