Conservation of a gene conversion mechanism in two distantly related paralogues of Anaplasma marginale.

@article{Meeus2003ConservationOA,
  title={Conservation of a gene conversion mechanism in two distantly related paralogues of Anaplasma marginale.},
  author={Patrick F. M. Meeus and Kelly A. Brayton and Guy H. Palmer and Anthony F. Barbet},
  journal={Molecular microbiology},
  year={2003},
  volume={47 3},
  pages={633-43}
}
Anaplasmataceae, the causative agents of anaplasmosis and ehrlichiosis, persist in the bloodstream of their mammalian hosts, allowing acquisition and transmission by tick vectors. Anaplasma marginale establishes persistent infection characterized by sequential cycles of rickettsaemia in which new antigenic variants emerge. The two most immunodominant outer membrane proteins, MSP2 and MSP3, are paralogues, each encoded by a distinct family of related genes. This study demonstrates that, although… CONTINUE READING