Conservation of Robustness in a Gene Regulatory Network Underlying Circadian Rhythms

Abstract

The cellular genetic networks which underlie circadian rhythms in the fly and the mouse have generated lots of attention in experimental and modeling studies in the last 5 years. This architecture is remarkable from an engineering perspective, as it exhibits an enviable level of robustness in the face of uncertain stochastic perturbations, such as those which arise from intracellular constituents that are present in small numbers.

Cite this paper

@inproceedings{Doyle2004ConservationOR, title={Conservation of Robustness in a Gene Regulatory Network Underlying Circadian Rhythms}, author={Francis J. Doyle and J{\"{o}rg Stelling and Daniel E. Zak and Dieter Gilles}, year={2004} }