Conservation of RNA structures enables TNV and BYDV 5' and 3' elements to cooperate synergistically in cap-independent translation.

@article{Meulewaeter2004ConservationOR,
  title={Conservation of RNA structures enables TNV and BYDV 5' and 3' elements to cooperate synergistically in cap-independent translation.},
  author={Frank Meulewaeter and Rosalinde H Van Lipzig and Alexander P. Gultyaev and C. W. A. Pleij and Dani{\"e}l Van Damme and M. W. Cornelissen and Gerben van Eldik},
  journal={Nucleic acids research},
  year={2004},
  volume={32 5},
  pages={1721-30}
}
The subgenomic RNA 2 of tobacco necrosis virus A (TNV sgRNA2) encodes the viral coat protein, is unpolyadenylated and presumably uncapped. Here, we show that TNV sgRNA2 is translated cap independently. This cap-independent translation requires the leader and a 140 nt element of the trailer both in wheat germ extract and in tobacco protoplasts. Similar to barley yellow dwarf virus (BYDV), the TNV 5' and 3' elements stimulate translation synergistically. Computer-aided phylogenetic analysis of… CONTINUE READING

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Functionality of the STNV translational enhancer domain correlates with af®nity for two wheat germ factors

  • R. van Lipzig, M. Van Montagu, M. Cornelissen, F. Meulewaeter
  • Nucleic Acids Res.,
  • 2001

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