Conservation of DNA damage tolerance pathways from yeast to humans.

@article{Ulrich2007ConservationOD,
  title={Conservation of DNA damage tolerance pathways from yeast to humans.},
  author={Helle D Ulrich},
  journal={Biochemical Society transactions},
  year={2007},
  volume={35 Pt 5},
  pages={1334-7}
}
Damage tolerance mechanisms, which allow the bypass of DNA lesions during replication, are controlled in eukaryotic cells by mono- and poly-ubiquitination of the DNA polymerase cofactor PCNA (proliferating-cell nuclear antigen). In the present review, I will summarize our current knowledge of the enzymatic machinery for ubiquitination of PCNA and the way in which the modifications affect PCNA function during replication and lesion bypass in different organisms. Using the budding yeast as a… CONTINUE READING

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