Conservation and variation of the parapoxvirus GM-CSF-inhibitory factor (GIF) proteins.

Abstract

The GIF protein of orf virus (ORFV) binds and inhibits the ovine cytokines granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-2 (IL-2). An equivalent protein has so far not been found in any of the other poxvirus genera and we therefore investigated whether it was conserved in the parapoxviruses. The corresponding genes from both the… (More)
DOI: 10.1099/vir.0.006692-0

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