Conservation and evolution of the rpsU-dnaG-rpoD macromolecular synthesis operon in bacteria.

@article{Versalovic1993ConservationAE,
  title={Conservation and evolution of the rpsU-dnaG-rpoD macromolecular synthesis operon in bacteria.},
  author={James Versalovic and Thearith Koeuth and R. Kris Britton and Kati M. Geszvain and James R Lupski},
  journal={Molecular microbiology},
  year={1993},
  volume={8 2},
  pages={343-55}
}
The macromolecular synthesis (MMS) operon contains three essential genes (rpsU, dnaG, rpoD) whose products (S21, primase, sigma-70) are necessary for the initiation of protein, DNA, and RNA synthesis respectively. PCR amplifications with primers complementary to conserved regions within these three genes, and subsequent DNA sequencing of rpsU-dnaG PCR products, demonstrate that the three genes appear to be contiguous in 11 different Gram-negative species. Within the Gram-negative enteric… CONTINUE READING

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