Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants.

@article{Mattera2011ConservationAD,
  title={Conservation and diversification of dileucine signal recognition by adaptor protein (AP) complex variants.},
  author={Rafael Mattera and Markus B{\"o}hm and Rittik Chaudhuri and Yogikala Prabhu and Juan S Bonifacino},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 3},
  pages={2022-30}
}
The clathrin-associated, heterotetrameric adaptor protein (AP) complexes, AP-1, AP-2, and AP-3, recognize signals in the cytosolic domains of transmembrane proteins, leading to their sorting to endosomes, lysosomes, lysosome-related organelles, and/or the basolateral membrane of polarized epithelial cells. One type of signal, referred to as "dileucine-based," fits the consensus motif (D/E)XXXL(L/I). Previous biochemical analyses showed that (D/E)XXXL(L/I) signals bind to a combination of two… CONTINUE READING
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