Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis.

@article{Jackson2003ConservationAC,
  title={Conservation and cloning of CYP51: a sterol 14 alpha-demethylase from Mycobacterium smegmatis.},
  author={Colin J Jackson and David Christopher Lamb and Tim Marczylo and Josie Elizabeth Parker and Nigel L Manning and Diane Kelly and Steven L Kelly},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={301 2},
  pages={558-63}
}
The genetic locus encoding cytochrome P450 51 (CYP51; P450(14DM)) in Mycobacterium smegmatis is described here together with confirmation of activity in lanosterol 14 alpha-demethylation. The protein bound azole antifungals with high affinity and the rank order based on affinity matched the ranked order for microbiological sensitivity of the organism, thus… CONTINUE READING