Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.

  title={Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.},
  author={Richard N McLaughlin and Jacob T Gable and Cristina J. Wittkopp and Michael Emerman and Harmit Singh Malik},
  journal={Molecular biology and evolution},
  volume={33 8},
LINE-1 (long interspersed element-1) retroelements are the only active autonomous endogenous retroelements in human genomes. Their retrotransposition activity has created close to 50% of the current human genome. Due to the apparent costs of this proliferation, host genomes have evolved multiple mechanisms to curb LINE-1 retrotransposition. Here, we investigate the evolution and function of the LINE-1 restriction factor APOBEC3A, a member of the APOBEC3 cytidine deaminase gene family. We find… CONTINUE READING
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