Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom

@inproceedings{Shertz2010ConservationDA,
  title={Conservation, duplication, and loss of the Tor signaling pathway in the fungal kingdom},
  author={Cecelia A Shertz and Robert J. Bastidas and Wenjun Li and Joseph Heitman and Maria Eugenia Porras C{\'a}rdenas},
  booktitle={BMC Genomics},
  year={2010}
}
  • Cecelia A Shertz, Robert J. Bastidas, +2 authors Maria Eugenia Porras Cárdenas
  • Published in BMC Genomics 2010
  • Medicine, Biology
  • BackgroundThe nutrient-sensing Tor pathway governs cell growth and is conserved in nearly all eukaryotic organisms from unicellular yeasts to multicellular organisms, including humans. Tor is the target of the immunosuppressive drug rapamycin, which in complex with the prolyl isomerase FKBP12 inhibits Tor functions. Rapamycin is a gold standard drug for organ transplant recipients that was approved by the FDA in 1999 and is finding additional clinical indications as a chemotherapeutic and… CONTINUE READING

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