Consequences of prenatal toxin exposure for mental health in children and adolescents

  title={Consequences of prenatal toxin exposure for mental health in children and adolescents},
  author={Justin H. G. Williams and Louise C. Ross},
  journal={European Child \& Adolescent Psychiatry},
Drug use during pregnancy is common and the developing foetus may be exposed to a range of environmental toxins that have long-term consequences for neurodevelopment. We conducted a systematic review of the literature to explore the results of longitudinal cohort studies that have examined this question. Out of 2,977 abstracts identified, 7 previous systematic reviews and 95 original articles met further selection criteria. These mostly addressed the neurodevelopmental effects of exposure to… 

Substance exposure in utero and developmental consequences in adolescence: A systematic review

  • Tina Birk Irner
  • Psychology, Medicine
    Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence
  • 2012
Results showed that prenatal exposure to alcohol has long-term cognitive, behavioral, social, and emotional developmental consequences depending on amount and timing of exposure in utero.

Mental Health and care situation in school-aged children prenatally exposed to alcohol and other substances: a hospital based study

Assessment of mental health and investigate the care situation and use of supportive measures in a hospital-based population of schoolaged children prenatally exposed to alcohol and other substances, compared to a reference group.

Foetal effects of low-level alcohol use during pregnancy: what clinicians need to know

Foetal alcohol spectrum disorder is a spectrum of disorders in children associated with excessive prenatal alcohol exposure and is the leading known cause of non-genetic intellectual disability in the developed world.

The limbic-hypothalamic-pituitary-adrenal axis and the development of alcohol use disorders in youth.

Evidence suggests that LHPA dysfunction and stress play an important role in the development of AUD, and genetic liabilities, antenatal insults, maltreatment, and psychiatric illness appear to increase LHPA dysfunctional, raising risk for AUD.

Environmental Chemical Contributions to ADHD and the Externalising Disorders of Childhood - A Review of Epidemiological Evidence

externalising disorders of childhood, Attention Deficit hyperactivity Disorder (ADhD), conduct Disorder and Oppositional Defiant Disorder are leading causes of childhood morbidity. Aetiology is

Prenatal exposure to drugs: effects on brain development and implications for policy and education

It is important to close the gap between what science tells us about the impact of prenatal drug exposure on the fetus and the mother and what the authors do programmatically with regard to at-risk populations.

Health consequences of illegal drug use

Prospective evidence on illegal drug use in particular subpopulations may be needed to better understand health problems among users at different life stages and the possible long-term effects.

Environmental Risk Factors for Attention Deficit Hyperactivity Disorder and Implications for Clinical Practice

In this review, we have provided an overview of the environmental risk factors for attention deficit hyperactivity disorder (ADHD), focusing on the major environmental toxicants related to the



Growth, development, and behavior in early childhood following prenatal cocaine exposure: a systematic review.

There is no convincing evidence that prenatal cocaine exposure is associated with developmental toxic effects that are different in severity, scope, or kind from the sequelae of multiple other risk factors.

Caffeine use during pregnancy and child outcome: a 7-year prospective study.

Cognitive and motor outcomes of cocaine-exposed infants.

Cocaine-exposed children had significant cognitive deficits and a doubling of the rate of developmental delay during the first 2 years of life, and it is possible that these children will continue to have learning difficulties at school age.

Prenatal exposure to polychlorinated biphenyls and attention at school age.

These findings are consistent with earlier reports of greater vulnerability to prenatal PCB exposure in children who were not breast fed and are not clear whether the protection offered by breast-feeding is caused by nutrients in breast milk or better quality of intellectual stimulation often provided by Breast-feeding mothers.

Cognitive outcomes of preschool children with prenatal cocaine exposure.

Prenatal cocaine exposure was not associated with lower full-scale, verbal, or performance IQ scores but was associated with an increased risk for specific cognitive impairments and lower likelihood of IQ above the normative mean at 4 years.

Prenatal exposure to methylmercury and child development: influence of social factors.

Association of prenatal maternal or postnatal child environmental tobacco smoke exposure and neurodevelopmental and behavioral problems in children.

It is found that ETS exposure could cause subtle changes in children's neurodevelopment and behavior, however, studies to date are difficult to interpret because of the unknown influence of uncontrolled confounding factors, imprecision in measurements of smoking exposure, and collinearity of pre- and postnatal maternal smoking.

Foster placed children prenatally exposed to poly-substances

  • K. Slinning
  • Psychology
    European Child & Adolescent Psychiatry
  • 2004
The study suggests that even if children experience adequate care after birth, the accumulation of risk factors associated with prenatal substance exposure is still a potential contributor to impulsivity and attention-related problems in preschool children.

Consequences of lead exposure and iron supplementation on childhood development at age 4 years.