Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands

@article{Ansonoff2010ConsequencesOO,
  title={Consequences of opioid receptor mutation on actions of univalent and bivalent kappa and delta ligands},
  author={Michael A. Ansonoff and Philip S. Portoghese and John E. Pintar},
  journal={Psychopharmacology},
  year={2010},
  volume={210},
  pages={161-168}
}
IntroductionDuring the past decade, substantial evidence has documented that opioid receptor heterodimers form in cell lines expressing one or more opioid receptors. More recent studies have begun to investigate whether heterodimer formation also occurs in vivo.ObjectivesWe have used opioid receptor knockout mice to determine whether the in vivo intrathecal (i.t.) pharmacological potency of delta, kappa, and bivalent kappa/delta ligands is altered in the absence of the KOR-1 and/or DOR-1 genes… CONTINUE READING

Figures, Tables, and Topics from this paper.

References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Opioid pharmacology.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2005
VIEW 19 EXCERPTS