Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord.

@article{Enzmann2005ConsequencesON,
  title={Consequences of noggin expression by neural stem, glial, and neuronal precursor cells engrafted into the injured spinal cord.},
  author={Gaby U. Enzmann and Richard L. Benton and John Patrick Woock and Russell M Howard and Pantelis Tsoulfas and Scott R Whittemore},
  journal={Experimental neurology},
  year={2005},
  volume={195 2},
  pages={293-304}
}
Bone morphogenetic proteins (BMPs) are a large class of secreted factors, which serve as modulators of development in multiple organ systems, including the CNS. Studies investigating the potential of stem cell transplantation for restoration of function and cellular replacement following traumatic spinal cord injury (SCI) have demonstrated that the injured adult spinal cord is not conducive to neurogenesis or oligodendrogenesis of engrafted CNS precursors. In light of recent findings that BMP… CONTINUE READING