Corpus ID: 8824937

Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells.

@article{Hryniuk1975ConsequencesOM,
  title={Consequences of methotrexate inhibition of purine biosynthesis in L5178Y cells.},
  author={W. Hryniuk and L. Brox and J. F. Henderson and T. Tamaoki},
  journal={Cancer research},
  year={1975},
  volume={35 6},
  pages={
          1427-32
        }
}
Addition of 1 muM methotrexate to cultures of L5178Y cells results in an initial inhibition of thymidine, uridine, and leucine incorporation into acid-insoluble material followed, after about 10 hr, by a partial recovery in the extent of incorporation of these precursors. Acid-soluble adenosine triphosphate and guanosine triphosphate concentrations are greatly reduced initially, but guanosine triphosphate concentrations appear to recover partially by 10 hr. Acid-soluble uridine triphosphate and… Expand
Increase of phosphoribosylpyrophosphate levels in cultured L1210 leukemia cells exposed to methotrexate.
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References

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The mechanism of action of methotrexate in cultured L5178Y leukemia cells.
Purineless death as a link between growth rate and cytotoxicity by methotrexate.
Effects of A-methopterin on the purine biosynthesis of susceptible and resistant TA3 ascites cells.
The effect of A-methopterin on formate-C14 incorporation by mouse leukemias in vitro.
Isolation and characterization of ribosomes from L5178Y mouse lymphoma cells.
Effects of A-methopterin on formate incorporation into the nucleic acids of susceptible and resistant leukemic cells.
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