Consequences of manganese replacement of copper for prion protein function and proteinase resistance.

@article{Brown2000ConsequencesOM,
  title={Consequences of manganese replacement of copper for prion protein function and proteinase resistance.},
  author={David R Brown and Farida Hafiz and L L Glasssmith and Boon Seng Wong and Ian Matthew Jones and C Clive and Stephen John Haswell},
  journal={The EMBO journal},
  year={2000},
  volume={19 6},
  pages={1180-6}
}
The prion protein (PrP) binds copper and has antioxidant activity enhancing the survival of neurones in culture. The ability of the PrP to bind other cations was tested and it was found that only manganese could substitute for copper. Although initially manganese-loaded PrP exhibited similar structure and activity to copper-loaded PrP, after aging, manganese-loaded PrP became proteinase resistant and lost function. It was also found that manganese could be incorporated into PrP expressed by… CONTINUE READING

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Normal prion protein has superoxide dismutase-like activity

  • D. R. Brown, Wong, +4 authors I. M. Jones
  • Biochem. J.,
  • 1999
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