Consequences of lack of beta 1 integrin gene expression in mice.

  title={Consequences of lack of beta 1 integrin gene expression in mice.},
  author={Reinhard F{\"a}ssler and Markus Meyer},
  journal={Genes & development},
  volume={9 15},
beta 1 integrins are cell-surface receptors that mediate cell-cell and cell-matrix interactions. We have generated a null mutation in the gene for the beta 1 integrin subunit in mice and embryonic stem (ES) cells. Heterozygous mice are indistinguishable from normal littermates. Homozygous null embryos develop normally to the blastocyst stage, implant, and invade the uterine basement membrane but die shortly thereafter. Using beta 1 integrin-deficient ES cells we have established chimeric… CONTINUE READING
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