Consequences of ions and pH on the supramolecular organization of sphingomyelin and sphingomyelin/cholesterol bilayers.

@article{Chemin2008ConsequencesOI,
  title={Consequences of ions and pH on the supramolecular organization of sphingomyelin and sphingomyelin/cholesterol bilayers.},
  author={Caroline Chemin and Claudie Bourgaux and J Pean and Georg Pabst and Patrick W{\"u}thrich and Patrick Couvreur and Michel Ollivon},
  journal={Chemistry and physics of lipids},
  year={2008},
  volume={153 2},
  pages={119-29}
}
For drug delivery purpose the anticancer drug S12363 was loaded into ESM/Chol-liposomes using either a pH or an ammonium gradient. Association between the drug and the liposome depends markedly on the liposome membrane structure. Thus, ESM and ESM/Chol bilayer organization had been characterized by coupled DSC and XRDT as a function of both cholesterol concentration and aqueous medium composition. ESM bilayers exhibited a ripple lamellar gel phase P(beta') below the melting temperature and… CONTINUE READING

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