Consequences of growth hormone (GH) overexpression and GH resistance

@article{Bartke2002ConsequencesOG,
  title={Consequences of growth hormone (GH) overexpression and GH resistance},
  author={Andrzej Bartke and V. G. Chandrashekar and Brandi Lynn Bailey and Denise Zaczek and Daniel Turyn},
  journal={Neuropeptides},
  year={2002},
  volume={36},
  pages={201-208}
}
Development of transgenic mice overexpressing GH and GHR-KO mice with GH resistance provided novel animal models for study of the somatotropic axis and for identifying GH actions that may be relevant to its current and contemplated use in medicine and agriculture. Studies of phenotypic characteristics of these animals revealed previously unsuspected actions of GH and IGF-I on neuroendocrine functions related to reproduction and to the release of "stress hormones" (glucocorticoids and prolactin… CONTINUE READING
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