Consequences of complexity within biological networks: robustness and health, or vulnerability and disease.

@article{Dipple2001ConsequencesOC,
  title={Consequences of complexity within biological networks: robustness and health, or vulnerability and disease.},
  author={Katrina M. Dipple and James K Phelan and E. R. B. McCabe},
  journal={Molecular genetics and metabolism},
  year={2001},
  volume={74 1-2},
  pages={45-50}
}
One promise of molecular genetics for many of us was that a detailed knowledge of mutant alleles would permit accurate prediction of prognosis and better selection of therapeutic strategies for Mendelian disorders (1). This presumed predictive promise was naı̈ve and was based on a reductionist view of genotype-phenotype correlations, i.e., that a refined and specific knowledge of a mutation’s impact on protein structure and function would permit extrapolation to the phenotype of the intact… CONTINUE READING