Consequences of Hypothyroidism on Auditory System Function in Tshr Mutant (hyt) Mice

@article{Sprenkle2001ConsequencesOH,
  title={Consequences of Hypothyroidism on Auditory System Function in Tshr Mutant (hyt) Mice},
  author={Pamela M. Sprenkle and J. B. Mcgee and John M. Bertoni and Edward Joseph Walsh},
  journal={Journal of the Association for Research in Otolaryngology},
  year={2001},
  volume={2},
  pages={312-329}
}
The otological consequences of hypothyroidism and the outcome of thyroxin (T4) administration during the developmental period preceding the onset of hearing were examined in mice that express a point mutation in the gene encoding the thyrotropin receptor (Tshr), the so-called hyt mouse. Progeny of sires homozygous for the trait and heterozygous dams were injected with T4 or saline placebo from birth through the tenth postnatal day and auditory-evoked brainstem responses (ABRs) to acoustic… CONTINUE READING
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