Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung

  title={Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung},
  author={William J. Mach and Amanda R Thimmesch and J. Thomas Pierce and Janet Pierce},
  booktitle={Nursing research and practice},
Oxygen (O(2)) is life essential but as a drug has a maximum positive biological benefit and accompanying toxicity effects. Oxygen is therapeutic for treatment of hypoxemia and hypoxia associated with many pathological processes. Pathophysiological processes are associated with increased levels of hyperoxia-induced reactive O(2) species (ROS) which may readily react with surrounding biological tissues, damaging lipids, proteins, and nucleic acids. Protective antioxidant defenses can become… CONTINUE READING


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