Consequences of GATA-1 deficiency in megakaryocytes and platelets.

  title={Consequences of GATA-1 deficiency in megakaryocytes and platelets.},
  author={Pranav K. Vyas and Kevin Ault and Carl Jackson and Stuart H Orkin and Ramesh A. Shivdasani},
  volume={93 9},
In the absence of the hematopoietic transcription factor GATA-1, mice develop thrombocytopenia and an increased number of megakaryocytes characterized by marked ultrastructural abnormalities. These observations establish a critical role for GATA-1 in megakaryopoiesis and raise the question as to how GATA-1 influences megakaryocyte maturation and platelet production. To begin to address this, we have performed a more detailed examination of the megakaryocytes and platelets produced in mice that… CONTINUE READING
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