Consequence of nigrostriatal denervation and L-dopa therapy on the expression of glutamic acid decarboxylase messenger RNA in the pallidum.

Abstract

To examine the consequences of nigrostriatal denervation and L-dopa treatment on the basal ganglia output system, we analyzed, by quantitative in situ hybridization, the messenger RNA coding for glutamic acid decarboxylase (Mr 67,000) (GAD67 mRNA) in pallidal cells from patients with Parkinson's disease (PD), monkeys rendered parkinsonian by 1-methyl-4… (More)

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@article{Herrero1996ConsequenceON, title={Consequence of nigrostriatal denervation and L-dopa therapy on the expression of glutamic acid decarboxylase messenger RNA in the pallidum.}, author={M. T. Herrero and Richard J Levy and Merle Ruberg and M. R. Luquin and J. M. P{\'e}rez Villares and Javier Guillen and Baptiste Faucheux and F. Javoy-Agid and Jorge Guridi and Yves Agid and Jose A. Obeso and E. C. Hirsch}, journal={Neurology}, year={1996}, volume={47 1}, pages={219-24} }