Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn’s disease patients

@article{Braat2005ConsequenceOF,
  title={Consequence of functional Nod2 and Tlr4 mutations on gene transcription in Crohn’s disease patients},
  author={Henri Braat and Pieter C. F. Stokkers and Tijmen J. Hommes and Danny Cohn and Esther W M Vogels and Inge Pronk and Arnold Spek and Antoine H. C. van Kampen and Sander J. H. van Deventer and Maikel Peppelenbosch and Daniel W. Hommes},
  journal={Journal of Molecular Medicine},
  year={2005},
  volume={83},
  pages={601-609}
}
The concept that mutations in germ-line encoded pattern recognition receptors with immune activating functions are associated with an increased incidence in Crohn’s disease (CD) is gaining acceptance. Whether these mutations have similar or distinct effects on cellular physiology remains obscure. The incidence of three single nucleotide polymorphisms (SNPs) within the Nod2 gene and one functional SNP within both the Tlr4 and Tlr5 gene in a Dutch cohort of 637 patients with inflammatory bowel… CONTINUE READING