Consensus meeting: monosodium glutamate – an update

  title={Consensus meeting: monosodium glutamate – an update},
  author={Konrad Beyreuther and Hans Konrad Biesalski and John D. Fernstrom and Peter Grimm and Walter P. Hammes and Uwe Heinemann and Oliver S. Kempski and Peter Stehle and Hans Steinhart and Roger Walker},
  journal={European Journal of Clinical Nutrition},
Objective:Update of the Hohenheim consensus on monosodium glutamate from 1997: Summary and evaluation of recent knowledge with respect to physiology and safety of monosodium glutamate.Design:Experts from a range of relevant disciplines received and considered a series of questions related to aspects of the topic.Setting:University of Hohenheim, Stuttgart, Germany.Method:The experts met and discussed the questions and arrived at a consensus.Conclusion:Total intake of glutamate from food in… 

Use of monosodium glutamate in foods: the good, the bad, and the controversial side

The revised studies showed that MSG can reduce the amount of sodium in foods without modifying flavor, and the use of MSG is widely applied in industrial and homemade food.

Update on food safety of monosodium l-glutamate (MSG).

  • H. Henry-Unaeze
  • Biology, Medicine
    Pathophysiology : the official journal of the International Society for Pathophysiology
  • 2017

Monosodium glutamate: Review on clinical reports

This study aimed to shed light on the available literature from last 25 years about different clinical trials which had been carried out on animal and human models regarding possible effects of monosodium glutamate regarding increased hunger, food intake, and obesity in human subjects.

Monosodium glutamate ‘allergy’: menace or myth?

  • A. WilliamsK. Woessner
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 2009
This review prevents a critical review of the available literature related to the possible role of MSG in the so‐called ‘Chinese restaurant syndrome’ and in eliciting asthmatic bronchospasm, urticaria, angio‐oedema, and rhinitis.

Monosodium glutamate as a tool to reduce sodium in foodstuffs: Technological and safety aspects

An overview about salty and umami taste physiology, the potential applications of MSG use to reduce sodium content in specific industrialized foods and safety aspects of MSG as food additive are presented.

Conflict of interests and consensus meetings

The authors concluded that total intake of MSG in Europe lies within the considered safe range of consumption, and a formal recommendation is suggested to be included in the ‘Instruction for Authors’ regarding competing interests, to be shown in the published manuscript.

Monosodium Glutamate: Review on Preclinical and Clinical Reports

Preclinical studies showed that MSG administration was associated with obesity, cardiotoxicity, hepatotoxicity, kidney toxicity, neurotoxicity, anemia, spleen toxicity, lipid and glucose metabolism alteration, negative effects of fertility, coagulant system, and microbiota, however, clinical studies have focused mostly on MSG effects on appetite and energy expenditure.

Mini Review About Monosodium Glutamate

A need of full comprehension about MSG is necessary to give more attention in studying it, and advantage in the development of analysis methods and technical equipments should be exploited to obtain higher accuracy result.

Monosodium glutamate in a type 2 diabetes context: A large scoping review.

  • Jana El Tabbal
  • Medicine
    Regulatory toxicology and pharmacology : RTP
  • 2022

Risk Assessment Paradigm for Glutamate

A 3-generation reproductive toxicity study in mice that includes extensive brain histopathology, provides a better point of departure showing no effects up to the highest dose tested of 6,000 mg/kg bw/day, and there is no compelling evidence to indicate that the previous ADI of “not specified” warrants any change.



The safety evaluation of monosodium glutamate.

A subsequent review by the Federation of American Societies for Experimental Biology and the Federal Drug Administration did not discount the existence of a sensitive subpopulation but otherwise concurred with the safety evaluation of JECFA and the SCF.

International Symposium on Glutamate. Introduction to the symposium proceedings.

It is decided that a great deal of benefit might accrue from a second international (and interdisciplinary) glutamate symposium, held in October, 1998 at the Clinical Research Center for Rare Diseases Aldo e Cele Daccó of the Mario Negri Institute for Pharmacological Research in Bergamo Italy.

Pulmonary reactions to monosodium glutamate

While MSG may precipitate bronchospasm in a small group of selected patients, this association remains to be validated in double‐blind placebo controlled studies.

Monosodium glutamate sensitivity in asthma.

Monosodium glutamate-induced asthma: study of the potential risk of 30 asthmatics and review of the literature.

It is concluded that a very small subset of patients with intrinsic asthma might present with an intolerance to MSG if high doses are consumed.

The effects of monosodium glutamate in adults with asthma who perceive themselves to be monosodium glutamate-intolerant.

Monosodium glutamate and asthma.

The existence of MSG-induced asthma, even in history-positive patients, has not been established conclusively and there is a >95% probability that MSG history-negative asthmatic patients are not sensitive to MSG.

Monosodium glutamate-induced asthma: study of the potential risk of 30 asthmatics and review of the literature.

It is concluded that a very small subset of patients with intrinsic asthma might present with an intolerance to MSG if high doses are consumed.

The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study.

Monosodium L-glutamate-induced asthma.