Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation

@article{Abraham2000ConsensusCD,
  title={Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation},
  author={Edward Abraham and Michael A. Matthay and Charles A. Dinarello and Jean Louis Vincent and Jonathan Cohen and Steven M. Opal and Michel Pierre Glauser and Polly E. Parsons and Charles Jack Fisher and John E. Repine},
  journal={Critical Care Medicine},
  year={2000},
  volume={28},
  pages={232–235}
}
&NA; Definitions for sepsis, septic shock, acute lung injury (ALI), and acute respiratory distress syndrome (ARDS) were developed by consensus conferences with the goal of achieving standardization of terminology and improved homogeneity of patient populations in clinical studies. Although such definitions have been useful in epidemiologic investigations, the criteria specified by the consensus conferences are broad and insufficiently specific to address the problem of heterogeneous mechanisms… 
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Here, a review of the recent randomized, clinical trials of ALI/ARDS is reviewed, finding that effective results in the animal models are not equally adoptive to those in randomized, controlled trials.
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How acute respiratory distress syndrome is defined has a significant impact on the results of randomized, controlled trials and epidemiologic studies and can contribute to clinical trials that have failed to detect a potential true treatment effect.
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Therapeutic success against sepsis depends on the appropriate use of antibiotics, on the treatment of hemodynamic and respiratory disorder and on general supportive care, and in some cases the use of activated protein C is to take in consideration.
Acute lung injury and the acute respiratory distress syndrome: challenges in clinical trial design.
The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection.
Animal Models ofSepsis
TLDR
The use of animal models has been proposed as a valuable tool in the study of sepsis and the need to advance understanding of this complex disease and to develop new therapies that can improve patient outcomes remains a priority within the field of critical care medicine.
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