Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation
@article{Abraham2000ConsensusCD, title={Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation}, author={Edward Abraham and Michael A. Matthay and Charles A. Dinarello and Jean Louis Vincent and Jonathan Cohen and Steven M. Opal and Michel Pierre Glauser and Polly E. Parsons and Charles Jack Fisher and John E. Repine}, journal={Critical Care Medicine}, year={2000}, volume={28}, pages={232–235} }
&NA; Definitions for sepsis, septic shock, acute lung injury (ALI), and acute respiratory distress syndrome (ARDS) were developed by consensus conferences with the goal of achieving standardization of terminology and improved homogeneity of patient populations in clinical studies. Although such definitions have been useful in epidemiologic investigations, the criteria specified by the consensus conferences are broad and insufficiently specific to address the problem of heterogeneous mechanisms…
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References
SHOWING 1-10 OF 36 REFERENCES
Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine.
- MedicineChest
- 1992
Broad definitions of sepsis and the systemic inflammatory response syndrome were proposed, along with detailed physiologic parameters by which a patient may be categorized, and the use of severity scoring methods when dealing with septic patients was recommended as an adjunctive tool to assess mortality.
The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.
- MedicineAmerican journal of respiratory and critical care medicine
- 1994
The acute respiratory distress syndrome (ARDS), a process of nonhydrostatic pulmonary edema and hypoxemia associated with a variety of etiologies, carries a high morbidity, mortality (10 to 90%), and…
Identification of patients with acute lung injury. Predictors of mortality.
- MedicineAmerican journal of respiratory and critical care medicine
- 1995
If selection of patients using the new criteria for acute lung injury results in a significant change in the clinical characteristics, risk factors, or predictors of mortality when compared with prior studies of patients with adult respiratory distress syndrome, and to determine if a quantitative index of the severity of lung injury has prognostic value in identifying nonsurvivors of acute Lung injury.
Cytokine, complement, and endotoxin profiles associated with the development of the adult respiratory distress syndrome after severe injury
- MedicineCritical care medicine
- 1994
Results demonstrate that measurements of plasma concentrations of proinflammatory cytokines, endotoxin, or complement fragments are not helpful in predicting the development of ARDS after severe accidental injury.
The association of circulating endotoxin with the development of the adult respiratory distress syndrome.
- MedicineThe American review of respiratory disease
- 1989
It is suggested that the combination of endotoxin and complement fragments may be one mechanism involved in the development of ARDS.
Endothelial cell activity varies in patients at risk for the adult respiratory distress syndrome.
- MedicineCritical care medicine
- 1996
It is suggested that differences in endothelial cell activity exist between sepsis and trauma patients who are at risk for the development of ARDS.
Emerging therapies for sepsis and septic shock.
- Medicine, BiologyAnnals of the Academy of Medicine, Singapore
- 1998
Therapies against endotoxin, tumour necrosis factor, interleukin-1 and platelet activating factor did not reduce mortality and future effective therapies will probably use combination of agents depending upon the nature of the infection and the type of patient.
Markers for predicting the development of acute respiratory distress syndrome.
- Biology, MedicineAnnual review of medicine
- 1997
This chapter outlines the rationale for why accurately predicting the development of ARDS would be valuable and reviews the accumulated data on approaches for predicting ARDS and discusses the potential difficulties in establishing predictive markers.
Elevated von Willebrand factor antigen is an early plasma predictor of acute lung injury in nonpulmonary sepsis syndrome.
- Medicine, BiologyThe Journal of clinical investigation
- 1990
In patients with nonpulmonary sepsis, an elevated level of plasma vWf-Ag is a useful, early biochemical marker of endothelial injury and it has both predictive and prognostic value.
Treatment of Septic Shock with Human Monoclonal Antibody HA-1A
- MedicineAnnals of Internal Medicine
- 1994
A large, simple trial design to test the use of septic shock as an indication for HA-1A treatment and the effectiveness of 100 mg of HA- 1A and placebo in reducing the 14-day all-cause mortality rate in patients with sepsis who had gram-negative bacteremia was tested.