Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation

@article{Abraham2000ConsensusCD,
  title={Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: Time for a reevaluation},
  author={Edward Abraham and Michael A. Matthay and Charles A. Dinarello and Jean Louis Vincent and Jonathan Cohen and Steven M. Opal and Michel Pierre Glauser and Polly E. Parsons and Charles Jack Fisher and John E. Repine},
  journal={Critical Care Medicine},
  year={2000},
  volume={28},
  pages={232–235}
}
&NA; Definitions for sepsis, septic shock, acute lung injury (ALI), and acute respiratory distress syndrome (ARDS) were developed by consensus conferences with the goal of achieving standardization of terminology and improved homogeneity of patient populations in clinical studies. Although such definitions have been useful in epidemiologic investigations, the criteria specified by the consensus conferences are broad and insufficiently specific to address the problem of heterogeneous mechanisms… 
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378 Citations
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378 Citations

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The hypothesis that standard ARDS criteria applied to the trauma population will capture widely disparate forms of acute lung injury and are too nonspecific to identify a population at risk for prolonged respiratory failure and associated complications is tested.
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It is difficult to distinguish patients with true sepsis from those with severe inflammation due to non-infectious causes, so a more stringent description of “the septic profile” is needed.
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Severe Sepsis and Septic Shock: Defining the Clinical Problem
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    Scandinavian journal of infectious diseases
  • 2003
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A new conceptual framework for understanding sepsis, called the PIRO concept, has been developed, conceptually modeled from the TNM classification (tumor size, nodal spread, metastases) which has been successfully used in defining treatment and prognostic indicators in clinical oncology.
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How acute respiratory distress syndrome is defined has a significant impact on the results of randomized, controlled trials and epidemiologic studies and can contribute to clinical trials that have failed to detect a potential true treatment effect.
Acute lung injury review.
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Nosography of systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, and multiple organ dysfunction syndrome in internal medicine patients
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Therapeutic success against sepsis depends on the appropriate use of antibiotics, on the treatment of hemodynamic and respiratory disorder and on general supportive care, and in some cases the use of activated protein C is to take in consideration.
The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection.
Scientific and clinical challenges in sepsis.
TLDR
Novel inflammatory molecular aspects and the experimental anti-inflammatory strategies for sepsis are reviewed, as they may represent particular pathological processes in specific subsets of patients.
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