Consensus alignment for reliable framework prediction in homology modeling

@article{Prasad2003ConsensusAF,
  title={Consensus alignment for reliable framework prediction in homology modeling},
  author={Jahnavi C. Prasad and Stephen R. Comeau and Sandor Vajda and Carlos J. Camacho},
  journal={Bioinformatics},
  year={2003},
  volume={19 13},
  pages={1682-91}
}
MOTIVATION Even the best sequence alignment methods frequently fail to correctly identify the framework regions for which backbones can be copied from the template into the target structure. Since the underprediction and, more significantly, the overprediction of these regions reduces the quality of the final model, it is of prime importance to attain as much as possible of the true structural alignment between target and template. RESULTS We have developed an algorithm called Consensus that… CONTINUE READING