Consensus Statement on 21-Hydroxylase Deficiency from The European Society for Paediatric Endocrinology and The Lawson Wilkins Pediatric Endocrine Society

@article{Clayton2002ConsensusSO,
  title={Consensus Statement on 21-Hydroxylase Deficiency from The European Society for Paediatric Endocrinology and The Lawson Wilkins Pediatric Endocrine Society},
  author={Peter E. Clayton and Walter L. Miller and Sharon E. Oberfield and E. Martin Ritz{\'e}n and Wolfgang G. Sippell and Phyllis W Speiser},
  journal={Hormone Research in Paediatrics},
  year={2002},
  volume={58},
  pages={188 - 195}
}
Key Method1Writing Committee: Peter E. Clayton, Royal Manchester Children’s Hospital, Manchester, UK; Walter L. Miller*,University of California, San Francisco, Calif., USA; Sharon E. Oberfield, Columbia University, New York, N.Y., USA;E. Martin Ritzen, Karolinska Institute, Stockholm, Sweden; Wolfgang G. Sippell*, University Children’s Hospital,Kiel, Germany; Phyllis W. Speiser, New York University, New York, N.Y. (*co-chairs)

Regarding the consensus statement on 21-hydroxylase deficiency from the Lawson Wilkins Pediatric Endocrine Society and the European Society for Paediatric Endocrinology.

This statement is concerned exclusively with CAH caused by 21-hydroxylase deficiency and does not address the other rarer forms of CAH.

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A brief overview of the most recent expert opinion and clinical practice guidelines for CAH as formulated by The Endocrine Society Task Force is given.

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The 2002 consensus statement recommendations for the management of classical congenital adrenal hyperplasia due to 21-hydroxylase deficiency are interpreted and translated into medical, surgical and mental health protocols and preliminary evidence that such protocols result in improved care and support for patients and families is provided.

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It is demonstrated that there is general agreement among paediatric endocrinologists in Canada regarding the management of patients with CAH, which includes very little use of newer antiandrogen therapies.

Guidelines for diagnosis and treatment of 21-hydroxylase deficiency (2014 revision)

  • T. IshiiM. Anzo T. Tajima
  • Medicine
    Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology
  • 2015
The “Guidelines for Treatment of Congenital Adrenal Hyperplasia (21-Hydroxylase Deficiency) Found in Neonatal Mass Screening (1999 revision)” published in 1999 were revised to include 21-OHD patients with very mild or no clinical symptoms.

Congenital adrenal hyperplasia due to steroid 21-hydroxylase deficiency: an Endocrine Society clinical practice guideline.

Clinical practice guidelines for congenital adrenal hyperplasia (CAH) recommend universal newborn screening for severe steroid 21-hydroxylase deficiency followed by confirmatory tests and recommend judicious use of medication during pregnancy and in symptomatic patients with nonclassic CAH.

Treatment and Outcome of Congenital Adrenal Hyperplasia: 21-Hydroxylase Deficiency

This special issue of the International Journal of Pediatric Endocrinology is intended to review the state of the art in medical treatment and psychological management as well as evaluations of the outcomes of patients with CAH.

Prenatal dexamethasone treatment for classic 21-hydroxylase deficiency in Europe

A high international variability and discrepancy in the use of Pdex treatment across Europe is revealed, highlighting the importance of a European cooperation initiative for a joint international prospective trial to establish evidence-based guidelines on prenatal diagnostics, treatment and follow-up of pregnancies at risk for CAH.

Endocrine Society Congenital Adrenal Hyperplasia Guidelines: Great content but how to deliver?

The guidelines provide a balanced account of the clinical care that should be provided for children, young people and young adults at the end of the first decade of the 21st century and concerns the use of antenatal treatment with dexamethasone.
...

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