Consenso brasileiro para a abordagem clínica e tratamento do hipotireoidismo subclínico em adultos: recomendações do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia

  title={Consenso brasileiro para a abordagem cl{\'i}nica e tratamento do hipotireoidismo subcl{\'i}nico em adultos: recomendaç{\~o}es do Departamento de Tireoide da Sociedade Brasileira de Endocrinologia e Metabologia},
  author={Jos{\'e} Augusto Sgarbi and Patr{\'i}cia de F{\'a}tima dos Santos Teixeira and L{\'e}a Maria Zanini Maciel and Gl{\'a}ucia Maria Ferreira da Silva Mazeto and M{\'a}rio Vaisman and Renan Magalh{\~a}es Montenegro J{\'u}nior and Laura S. Ward},
  journal={Arquivos Brasileiros De Endocrinologia E Metabologia},
INTRODUCTION: Subclinical hypothyroidism (SCH), defined as elevated concentrations of thyroid stimulating hormone (TSH) despite normal levels of thyroid hormones, is highly prevalent in Brazil, especially among women and the elderly. Although an increasing number of studies have related SCH to an increased risk of coronary artery disease and mortality, there have been no randomized clinical trials verifying the benefit of levothyroxine treatment in reducing these risks, and the treatment… 

Management of gestational hypothyroidism: results of a Brazilian survey.

OBJECTIVES Evaluate the management of hypothyroidism in fertile-aged and pregnant women and compare these practices to the recommendations of the Brazilian Society of Endocrinology and Metabolism

Effect of Levothyroxine on Older Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-Analysis

Among older SCH patients, levothyroxine treatment may reduce TC, TG, LDL-C, and apolipoprotein B, and ApoB, and lev Timothyroxine had no significant effect on bone mineral density, fatigue, hypothyroidism symptoms, quality of life, BMI, cognitive function, depression, blood pressure, etc.

Conduta acerca do hipotireoidismo subclínico / Approach of subclinical hypothyroidism

The normal dynamics of thyroid function and its main dysfunctions are presented and the various conditions of the diagnosis and conduct are analyzed, and a critical analysis of the published studies on the subject is made, evaluating its methodologies and identifying contradictory points in the comparison between studies.

Prevalence of thyroid dysfunctions in patients attended at the Clinical Laboratory of the Military Police Hospital of the Goias State in the period from 2015 to 2016

Subclinical hypothyroidism was more prevalent in women, being justified by advanced age, menopause and greater demand for health services, and the adoption of Free T4 is fundamental when the TSH has limitations.

Laparoscopic Sleeve Gastrectomy has A Positive Impact on Subclinical Hypothyroidism Among Obese Patients: A Prospective Study

The positive effect of the LSG procedure on the hypothyroid bariatric population, including enhanced thyroid function, was demonstrated and correlated significantly with serum cholesterol and triglyceride levels.

Thyroid function before and after Roux-en-Y gastric bypass: an observational study.

Detection of Alterations in the Gut Microbiota and Intestinal Permeability in Patients With Hashimoto Thyroiditis

Evaluated alterations in the gut microbiota in Brazilian patients with HT and correlated this data with dietary habits, clinical data, and systemic cytokines and zonulin concentrations, suggesting a leaky gut in patients withHT.

Redução e/ou negativação dos anticorpos antitireoidianos com tratamento homeopático: série de casos

9 cases corresponding to female patients, age 31 to 56 old, diagnosed with autoimmune thyroiditis, who exhibited reduced or negative anti-thyroid antibodies after homeopathic treatment, and normal function of thyroid was additionally achieved.

A Systematic Review of Clinical Practice Guidelines' Recommendations on Levothyroxine Therapy Alone versus Combination Therapy (LT4 plus LT3) for Hypothyroidism.

  • Eyal KrautP. Farahani
  • Medicine, Biology
    Clinical and investigative medicine. Medecine clinique et experimentale
  • 2015
Clinical practice guidelines worldwide do not recommend and do not support routine use of combination LT4 and LT3 therapy to treat hypothyroidism, and only the 2012 ETA Guidelines and the 2015 BTA Guidelines concluded that combination therapy could be used, although only in certain circumstances and as an experimental treatment.



Avaliação clínica e de sintomas psiquiátricos no hipotireoidismo subclínico

The study showed that SH was associated with clinical findings and with psychiatric symptoms, and there was no association between the clinical and psychiatric findings and the etiology of SH, presence of ATPO, age or menopause.

atualizacão Disfunções Mínimas da Tiróide: Hipotiroidismo Subclínico e Hipertiroidismo Subclínico

In SHT, total cholesterol and LDL-C are modestly elevated and levothyroxine may influence the lipids levels, and there is decreased cardiac contractility and increased peripheral vascular resistance that improve with treatment.

How good is the levothyroxine replacement in primary hypothyroidism patients in Brazil? Data of a multicentre study

Clinicians should consider monitoring patients on thyroid replacement more frequently and being more precise on giving recommendations about the correct use of LT4, found that a significant number of patients taking thyroid hormones were not in the therapeutic range.

Subclinical Hyperthyroidism and Pregnancy Outcomes

Evaluated pregnancy outcomes in women with suppressed thyroid-stimulating hormone (TSH) and normal free thyroxine (fT4) levels indicated that identification of subclinical hyperthyroidism and treatment during pregnancy is unwarranted.

Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association.

Fifty-two evidence-based recommendations and subrecommendations were developed to aid in the care of patients with hypothyroidism and to share what the authors believe is current, rational, and optimal medical practice for the diagnosis and care of hyp Timothyroidism.

The influence of age on the relationship between subclinical hypothyroidism and ischemic heart disease: a metaanalysis.

SCH is associated with increased IHD (both prevalence and incidence) and cardiovascular mortality only in subjects from younger populations, suggesting that increased vascular risk may only be present in younger individuals with SCH.

The clinical significance of subclinical thyroid dysfunction.

The mechanisms underlying tissue alterations in SCTD and the effects of replacement therapy on progression and tissue parameters are examined, and the issue of the need to treat slight thyroid hormone deficiency or excess in relation to the patient's age is addressed.

Clinical features and outcome of subacute thyroiditis in an incidence cohort: Olmsted County, Minnesota, study.

Subacute thyroiditis (SAT), or granulomatous thyroiditis, is an inflammatory thyroid condition associated with pain and systemic symptoms andSymptomatic relief is achieved with corticosteroid therapy, but such therapy does not prevent early- and late-onset thyroid dysfunction.

Subclinical thyroid disease: scientific review and guidelines for diagnosis and management.

The strength of the evidence that untreated subclinical thyroid disease is associated with clinical symptoms and adverse clinical outcomes was assessed and recommendations for clinical practice developed and insufficient evidence to support population-based screening was found.

Changes in bone mass during prolonged subclinical hyperthyroidism due to L-thyroxine treatment: a meta-analysis.

A meta-analysis on the available papers found that preserved estrogen production plays a protective role against irreversible bone loss in women with suppressed serum TSH due to L-T4 treatment and in a control group, and the risk of not detecting an excess bone loss of at least 1% per year was p < 0.15.