Consanguinity around the world: what do the genomic data of the HGDP-CEPH diversity panel tell us?

@article{Leutenegger2011ConsanguinityAT,
  title={Consanguinity around the world: what do the genomic data of the HGDP-CEPH diversity panel tell us?},
  author={Anne-Louise Leutenegger and Mourad Sahbatou and Steven Gazal and Howard M. Cann and Emmanuelle G{\'e}nin},
  journal={European Journal of Human Genetics},
  year={2011},
  volume={19},
  pages={583-587}
}
Inbreeding coefficients and consanguineous mating types are usually inferred from population surveys or pedigree studies. Here, we present a method to estimate them from dense genome-wide single-nucleotide polymorphism genotypes and apply it to 940 unrelated individuals from the Human Genome Diversity Panel (HGDP-CEPH). Inbreeding is observed in almost all populations of the panel, and the highest inbreeding levels and frequencies of inbred individuals are found in populations of the Middle… CONTINUE READING
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