Conotoxins and the posttranslational modification of secreted gene products

  title={Conotoxins and the posttranslational modification of secreted gene products},
  author={O. Buczek and G. Bulaj and B. Olivera},
  journal={Cellular and Molecular Life Sciences CMLS},
  • O. Buczek, G. Bulaj, B. Olivera
  • Published 2005
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • Abstract.The venoms of predatory cone snails (genus Conus) have yielded a complex library of about 50–100,000 bioactive peptides, each believed to have a specific physiological target (although peptides from different species may overlap in their target specificity). Conus has evolved the equivalent of a drug development strategy that combines the accelerated evolution of toxin sequences with an unprecedented degree of posttranslational modification. Some Conus venom peptide families are the… CONTINUE READING
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