Connexins protect mouse pancreatic β cells against apoptosis.

  title={Connexins protect mouse pancreatic β cells against apoptosis.},
  author={Philippe Klee and Florent Allagnat and Helena Pontes and Manon Cederroth and Anne Charollais and Doroth{\'e}e Caille and Aurore Britan and J. A. Haefliger and Paolo Meda},
  journal={The Journal of clinical investigation},
  volume={121 12},
Type 1 diabetes develops when most insulin-producing β cells of the pancreas are killed by an autoimmune attack. The in vivo conditions modulating the sensitivity and resistance of β cells to this attack remain largely obscure. Here, we show that connexin 36 (Cx36), a trans-membrane protein that forms gap junctions between β cells in the pancreatic islets, protects mouse β cells against both cytotoxic drugs and cytokines that prevail in the islet environment at the onset of type 1 diabetes. We… CONTINUE READING
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