Connexins in the sinoatrial and atrioventricular nodes.

  title={Connexins in the sinoatrial and atrioventricular nodes.},
  author={Mark R. Boyett and Shin Inada and Shin Yoo and Jinshen Li and Jie Liu and J T{\'e}llez and Ian D. Greener and Haruo Honjo and Rudolf Billeter and Ming Lei and Henggui Zhang and Igor R. Efimov and Halina Dobrzynski},
  journal={Advances in cardiology},
The sinoatrial node (SAN) and the atrioventricular node (AVN) are specialized tissues in the heart: the SAN is specialized for pacemaking (it is the pacemaker of the heart), whereas the AVN is specialized for slow conduction of the action potential (to introduce a delay between atrial and ventricular activation during the cardiac cycle). These functions have special requirements regarding electrical coupling and, therefore, expression of connexin isoforms. Electrical coupling in the center of… CONTINUE READING

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