Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets

@inproceedings{Vicario2017ConnexinsIT,
  title={Connexins in the Central Nervous System: Physiological Traits and Neuroprotective Targets},
  author={Nunzio Vicario and Agata Zappal{\`a} and Giovanna Calabrese and Rosario Gulino and Carmela Parenti and Massimo Gulisano and Rosalba Parenti},
  booktitle={Front. Physiol.},
  year={2017}
}
Cell-to-cell interaction and cell-to-extracellular environment communication are emerging as new therapeutic targets in neurodegenerative disorders. Dynamic expression of connexins leads to distinctive hemichannels and gap junctions, characterized by cell-specific conduction, exchange of stimuli or metabolites, and particular channel functions. Herein, we briefly reviewed classical physiological traits and functions of connexins, hemichannels, and gap junctions, in order to discuss the… CONTINUE READING
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