Connexins in mammalian heart function.

  title={Connexins in mammalian heart function.},
  author={Daniel B Gros and Habo J. Jongsma},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={18 9},
In heart, the propagation of electrical activity is mediated by intercellular channels, referred to as junctional channels, aggregated into gap junctions and localised between myocytes. These channels consist of structurally related transmembrane proteins, the connexins, three of which (CX43, CX40 and CX45) have been shown to be associated with the myocytes of mammalian heart; a fourth, CX37, was detected exclusively in endothelial cells. In this paper, we review the recent data dealing with… CONTINUE READING

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